Research Dosing

SLU-PP-332

SLU-PP-332 is a small-molecule pan-agonist of estrogen-related receptors that stimulates the production of new mitochondria, increases ATP synthesis, and is an “exercise mimetic”- a substance that activates certain chemical processes in the body that mimic the effects of intense aerobic activity on a cellular lever without physical activity.

Benefits

  • Boosts energy
  • Increases energy expenditure
  • Promotes efficient fat oxidation
  • Improved VO2 max
  • Ideal for abdominal fat reduction
  • Enhanced capillary density in muscle
  • Shift toward oxidative muscle fibers
  • Increases fatty acid metabolism
  • Reduces fat
  • Improves endurance and stamina
  • Enhances glucose uptake and insulin sensitivity, which can help regulate blood sugar and help to combat insulin resistance
  • Preserves lean muscle mass
  • Supports muscle function and faster recovery
  • Higher mitochondrial content
  • Reversal of hepatic steatosis
  • Reduced inflammation in liver and adipose tissue
  • Improves cardiovascular health by enhancing oxygen utilization and fat oxidation
  • Prevents blocked arteries caused by a buildup of cholesterol
  • Upregulates mitophagy (the removal of damaged mitochondria)
  • Good for post-infarction metabolic support
  • Suppresses age-associated inflammatory markers (including IL-6, TNF-a, CRP)
  • Supports autophagy, mitophagy, and fibrosis attenuation in organs like the liver, heart, and kidney
  • Helps with metabolic dysfunction-related hormonal imbalances

Possible Side Effects

  • Restlessness
  • Heat intolerance
  • Insomnia
  • Gastrointestinal upset
  • Increase in heart rate and blood pressure

Interactions

  • Use caution when using SLU-PP-332 and stimulants or thermogenics (e.g. methamphetamine, cocaine, high caffeine, ephedrine, yohimbine): may cause an additive heart rate/blood pressure strain
  • Use caution when using thyroid medications (e.g. levothyroxine, liothyronine), as it may effect the efficacy of the medications and necessitate a dose change or have additive effects on mitochondrial programs
  • Use caution when using diabetic drugs (insulin, sulfonylureas): if combined with potent weight loss agents, watch for hypoglycemia as insulin sensitivity improves

Contraindications

  • Do not use if you are pregnant or breastfeeding
  • Do not use if you have or suspect you may have a hormone-sensitive cancer (breast, prostate, thyroid) or active neoplasia
  • Do not use if you have uncontrolled cardiovascular disease, arrhythmias, or uncontrolled hyperthyroidism
  • Do not use if you have severe liver or kidney impairment

SLU-PP-332: 1,000MCGS — DOSING

No cycling necessary.

Take 2-3 capsules per day