šŸ”“ IMPORTANT: Read This Before Proceeding With Dosing:
Go to the Prep & Injection Guide for proper reconstitution, syringe sizing, and injection protocols. Mistakes here can compromise your research.

šŸ‘‰ Click here to read the Prep & Injection Guide

5-Amino-1MQ (5-Amino-methylquinolinium) is a small molecule compound designed to inhibit the enzyme NNMT (nicotinamide N-methyltransferase), which plays a key role in metabolic regulation and fat cell activity. By suppressing NNMT, 5-Amino-1MQ increases NADāŗ levels and helps to accelerate energy metabolism, support healthy body composition, and reduce fat massā€”especially visceral fat. It has gained attention for its potential to improve insulin sensitivity, mitochondrial function, and cellular repair, making it a popular option in fat loss, longevity, and athletic performance protocols.

KEY BENEFITS

  • Promotes rapid fat loss without muscle breakdown
  • Inhibits fat cell growth and reduces existing fat deposits
  • NAD+ preservation: NAD+ is essential for mitochondrial function, which is central to the production of energy (ATP) within cells. As we age, NAD+ levels naturally decline, which can impair cellular energy production and lead to aging-related diseases. 5-Amino-1MQā€™s ability to inhibit CD38 and preserve NAD+ levels is of significant interest for anti-aging and longevity research.
  • Mitochondrial Biogenesis: 5-Amino-1MQ may also contribute to mitochondrial biogenesis, which refers to the generation of new mitochondria in cells. Mitochondria are responsible for energy production, and an increase in their numbers can improve overall cellular function and endurance.
  • Improves glucose uptake and reduces insulin resistance
  • Cognitive Health: By improving mitochondrial health and NAD+ levels, 5-Amino-1MQ may help protect brain cells from age-related neurodegenerative diseases like Alzheimerā€™s and Parkinsonā€™s disease. NAD+ is essential for neuronal function and survival.
  • Increased Brain Energy: The compoundā€™s potential to enhance mitochondrial function could improve energy metabolism in the brain, supporting cognitive performance and possibly reducing brain fatigue
  • Supports cellular longevity and anti-aging effects
  • Improved Endurance: By enhancing mitochondrial activity and fat oxidation, 5-Amino-1MQ could improve physical endurance and exercise capacity. This may be particularly beneficial for endurance athletes or anyone looking to increase their stamina.
  • May assist in reducing inflammation and oxidative stress
  • Inhibits NNMT in adipose tissue, leading to smaller fat cells and reduced fat mass
  • Muscle Preservation: Because 5-Amino-1MQ promotes fat loss rather than muscle loss, it may help maintain lean muscle mass while reducing body fat. This makes it an attractive option for individuals undergoing body composition changes.

MECHANISM OF ACTION

5-Amino-1MQ works primarily by:

  • NNMT Inhibition: Suppresses the enzyme responsible for downregulating energy metabolism in fat cells
  • NADāŗ Elevation: Increases intracellular NADāŗ, enhancing mitochondrial function and energy production
  • Mitochondrial Optimization: Promotes thermogenesis and lipid oxidation via improved mitochondrial efficiency

The result is an upregulation of cellular metabolism, reduced fat accumulation, and improved lean body mass.

POSSIBLE SIDE EFFECTS

Common (usually temporary and mild):

  • Headache
  • Mild fatigue
  • Digestive discomfort (bloating, nausea)
  • Mild increase in heart rate

Rare:

  • Skin irritation or redness at injection site
  • Dizziness or jitteriness
  • Temporary sleep disturbances

SIDE EFFECT MANAGEMENT

  • Stay hydrated and eat balanced meals during the protocol
  • Reduce dosage if fatigue or nausea occurs
  • Use smaller split doses if needed to increase tolerance

CONTRAINDICATIONS

Do NOT use 5-Amino-1MQ if:

  • You are pregnant or breastfeeding
  • You have uncontrolled cardiovascular conditions
  • You have liver or kidney impairment
  • You are allergic to any excipients or BAC
  • You are on medications that alter NAD metabolism without physician oversight

SYNERGISTIC STACKS

  • Works particularly well when paired with non-stimulant thermogenics, e.g. DHEA and ZMT
  • BCAA 2:1:1 in either CAPSULE or POWDER form
  • Tesamorelin: maximizes fat loss effects
  • BPC-157: for reduced downtime from intensive workout regimen
  • CJC 1295 No Dac w/Ipamorelin: boosts growth hormone for enhanced metabolic effect
  • Epithalon: for longevity, immune health, and circadian rhythm support
  • IGF-1 LR3: complements 5-Amino-1mq in recomposition and post-cycle protocols
  • Glutathione or NAD+: to amplify anti-aging and mitochondrial repair benefits
  • GLP-1’s: supports appetite suppression and insulin regulation

5-AMINO-1MQ: 10MG RECONSTITUTION AND DOSING PROTOCOLS

Cycle Length: 4-8 week cycles followed by a 2-4 week washout period

Frequency: Daily (due to the short cycle length, dosing is daily rather than 5 days per week)

Timing: May be taken any time of day, although morning or afternoon is preferred

Fasting Requirements: Does not need to be taken while fasting, although GI side effects may be mitigated by dosing along with a light meal

Route of Administration: Subcutaneous Administration

Reconstitution Solution(s): Bacteriostatic water

Recommended Dosing Syringe(s): 30 gauge, 1mL, 5/16″

Special Storage Requirements: Best practice is to store both lyophilized and reconstituted peptides under refrigeration. When properly stored, lyophilized peptide may be refrigerated for up to one year, while reconstituted peptide solutions should generally not be stored for longer than 60 days. For extended storage, lyophilized peptide may be frozen for up to three years.

If freezing 5-Amino-1MQ, avoid unnecessary freezeā€“thaw cycles. The product should remain frozen until it is being prepared for use, as repeated freezing and thawing may adversely affect peptide stability and integrity.

To minimize the potential for moisture exposure and condensation, transfer the frozen lyophilized peptide directly to the refrigerator and allow it to thaw completely under refrigerated conditions rather than bringing it immediately to room temperature.

Once fully thawed, the vial may be moved to a room-temperature environment away from direct sunlight and allowed to gradually reach room temperature before reconstitution. Bacteriostatic water should also be allowed to reach room temperature before being introduced into the vial. This helps minimize abrupt temperature changes during the reconstitution process and supports appropriate handling of the peptide.

4-Week Minimum Protocol

Mix with 2mL (200 units) of BAC water

  • Weeks 1-2: Take 20 units (1mg), 1x/day
  • Weeks 3-4: Take 40 units (2mg), 1x/day

Mix with 2mL (200 units) of BAC water

  • Weeks 1-4: 20 units (1mg), 1x/day
  • Weeks 5-8: 40 units (2mg), 1x/day OR continue with 20 units (1mg) for duration of cycle

Standard Protocol (Recommended)

Mix with 2mL (200 units) of BAC water

  • Week 1: 20 units (1mg), 1x/day
  • Week 2-3: 40 units (2mg), 1x/day
  • Weeks 3-4: 60 units (3mg), 1x/day
  • Weeks 5-6: 80 units (4mg), 1x/day
  • Weeks 7-8: 100 units (5mg), 1x/day

5-AMINO-1MQ: 50MG RECONSTITUTION AND DOSING PROTOCOLS

Cycle Length: 4-8 week cycles followed by a 2-4 week washout period

Frequency: Daily (due to the short cycle length, dosing is daily rather than 5 days per week)

Timing: May be taken any time of day, although morning or afternoon is preferred

Fasting Requirements: Does not need to be taken while fasting, although GI side effects may be mitigated by dosing along with a light meal

Route of Administration: Subcutaneous Administration

Reconstitution Solution(s): Bacteriostatic water

Recommended Dosing Syringe(s): 30 gauge, 1mL, 5/16″

Special Storage Requirements: Best practice is to store both lyophilized and reconstituted peptides under refrigeration. When properly stored, lyophilized peptide may be refrigerated for up to one year, while reconstituted peptide solutions should generally not be stored for longer than 60 days. For extended storage, lyophilized peptide may be frozen for up to three years.

If freezing 5-Amino-1MQ, avoid unnecessary freezeā€“thaw cycles. The product should remain frozen until it is being prepared for use, as repeated freezing and thawing may adversely affect peptide stability and integrity.

To minimize the potential for moisture exposure and condensation, transfer the frozen lyophilized peptide directly to the refrigerator and allow it to thaw completely under refrigerated conditions rather than bringing it immediately to room temperature.

Once fully thawed, the vial may be moved to a room-temperature environment away from direct sunlight and allowed to gradually reach room temperature before reconstitution. Bacteriostatic water should also be allowed to reach room temperature before being introduced into the vial. This helps minimize abrupt temperature changes during the reconstitution process and supports appropriate handling of the peptide.

STANDARD PROTOCOL OPTION #1

Mix with 3mL (300 units) of BAC water

  • Week 1: 6 units (1mg), 1x/day
  • Week 2-3: 12 units (2mg), 1x/day
  • Weeks 3-4: 18 units (3mg), 1x/day
  • Weeks 5-6: 24 units (4mg), 1x/day
  • Weeks 7-8: 30 units (5mg), 1x/day

STANDARD PROTOCOL OPTION #2

Mix with 3mL (300 units) of BAC water

Days 1-3: 15 units (2.5mg) once per day, 7 days/week

Days 4-7 + weeks 2-6: 15 units (2.5mg) 2x/day, 7 days per week

LOW DOSE PROTOCOL (SINGLE DAILY DOSE)

Mix with 3mL (300 units) of BAC water

Days 1-3: 15 units (2.5mg) once per day, 7 days/week

Days 4-7: 30 units (5mg) once per day, 7 days/week

Weeks 2-6: 30 units (5mg) once per day, 7 days/week