Research Dosing

Kisspeptin

🔴 IMPORTANT: Read This Before Proceeding With Dosing
Go to the Prep & Injection Guide for proper reconstitution, syringe sizing, and injection protocols. Mistakes here can compromise your research.

👉 Click here to read the Prep & Injection Guide

Kisspeptin

Kisspeptin is a neuropeptide produced by the hypothalamus, a part of the brain that controls the release of several important hormones in the body including gonadotropin-releasing hormone (GnRh), luteinizing hormone (LH), and follicle-stimulating hormone (FSH). Kisspeptin plays a major role in reproductive function in both men and women, secretion of aldosterone (which regulates water and salt balance), tumor suppression, and kidney function. Kisspeptin was originally named Metastin, a direct reflection of its ability to prevent the spread of cancer.

Benefits

  • Increases testosterone levels by stimulating the release of LH, which in turn stimulates Leydig cells to produce testosterone
  • Boosts immunity
  • Regulates reproductive hormone release
  • Enhances fertility
  • Aids metabolic function and promotes weight loss
  • Prevents wrinkles and signs of aging
  • Boosts cognitive function
  • Increases liver antioxidants
  • Temporarily increases oxytocin
  • Boosts insulin secretion
  • Possible remedy for erectile dysfunction
  • Treats fertility disorders
  • Reacts with sexual stimuli and affects hormonal pulse frequency
  • Lowers risk of heart disease
  • Plays a role in puberty onset
  • Potential treatment for polycystic ovarian syndrome

Kisspeptin and Non-Alcoholic Fatty Liver Disease

Kisspeptin helps reduce fat already deposited in the liver and prevents its initial accumulation, making it beneficial for managing early-stage NAFLD.

How It Works

  • Binds to G-protein coupled receptors
  • Stimulates GnRH → stimulates LH, FSH, and sex steroid secretion
  • Increases testosterone, estrogen, progesterone
  • Increases HCG-stimulated progesterone secretion in luteal cells

Alternative to HCG

Kisspeptin may serve as a natural alternative to HCG for maintaining fertility and hormonal balance in testosterone therapy. It stimulates LH and testosterone production, helping restore the HPG axis.

Possible Side Effects (Very uncommon)

  • Diarrhea
  • Sweating
  • Headache
  • Hot flushes
  • Dizziness
  • Shortened menstrual cycle
  • Altered metabolism due to decreased food intake

Dosing Considerations

  • Effects last up to 24 hours after injection
  • LH/testosterone peak 45–60 minutes post-dose
  • Works best when fasted: fasting increases LH response 5–6x compared to fed state
  • Best results with 1mcg/kg bodyweight
  • Desensitization can occur if used too frequently
  • Optimal frequency: 2x/week

KISSPEPTIN: 5MG
Mix Kisspeptin: 5MG with 1.5mL (150 units) of BAC water
Subcutaneous Administration
Cycle: up to 50 days, followed by a 4-week washout

Initial Dose
200 mcg (6 units), 1x/day every other day
Start at the lowest dose. Increase only as tolerated and necessary to sustain benefits.

Dosing Scale

  • 6 units = 200mcg
  • 9 units = 300mcg
  • 12 units = 400mcg
  • 15 units = 500mcg

Alternative: Individualized Dosing Protocol

1 mcg per 2.204623 lbs body weight
Example: 210 lbs ÷ 2.204623 = 95.3 mcg
Use Omni Peptide Calculator

Start at calculated dose 2x/week, then increase in 100 mcg increments (up to 400 mcg max) as needed.

Stacking Suggestions

Kisspeptin can be effectively combined with:

  • HCG – For enhanced stimulation of LH and FSH
  • Tesamorelin or CJC-1295/Ipamorelin – Synergistic hormone support and fat loss
  • BPC-157 or TB-500 – Tissue repair and injury recovery
  • AOD-9604 – Amplifies fat loss effects
  • Tirzepatide or Semaglutide – Improves insulin sensitivity and body composition

For libido and fertility stacks:
Kisspeptin + PT-141 + HCG for synergistic effects on sex drive, hormone balance, and fertility