Dihexa, aka N-hexanoic-Tyr-lle-(6) aminohexanoic amideor PNB-0408, is a relatively new drug for the treatment of a wide array of conditions that affect cognitive function, including Alzheimer’s and Parkinson’s. Furthermore, it improves stroke recovery, accelerates recovery from spinal cord injury and nerve damage, and protects against hearing loss. Unlike other drugs for AD, this potent nootropic1 not only impedes the progression of the disease but actually repairs the damage in the synapse2 between neurons. By binding to hepatocyte growth factor (HGF), Dihexa increases HGF’s activity while lowering harmful chemical reactions in the body. This in turn doubles the capacity of the available growth factors to promote signaling cascades necessary for cell development and regeneration.
BENEFITS
- Aids in the treatment of Alzheimer’s and Parkinson’s diseases
- Improves cognitive function, particularly in such areas as memory retention and learning ability
- Improves stroke recovery
- Accelerates recovery from spinal cord injury and nerve damage
- Protects against hearing loss
- Aids in treating memory and motor dysfunctions by enhancing synaptic connectivity through the formation of new functional synapses
- Builds new brain cell connections
- Prevents learning and memory dysfunction after sustained cerebral ischemia (periods of decreased blood flow to the brain) by protecting injury to brain neurons
- Increases the production of acetylcholine and/or dopamine
- Activates HGF, which induces long-term neuroprotection and stroke recovery
- Prevents stroke by increasing blood flow to the brain
- Slows the progression of spinal cord injury caused by amyotrophic lateral sclerosis (ALS) Helps to heal damage to the sciatic nerve
POSSIBLE SIDE EFFECTS
- Anxiety
- Change of taste
- Insomnia
- Irritability
- Mood swings
- Nausea
- Headache
- Mental Overstimulation
- Light sensitivity
- Racing thoughts
- Increased focus bordering agitation Emotional intensity
INTERACTIONS
- Other strong neurotrophic agents: e.g. Cerebrolysin, Semax/NA-Semax, Selank, NSI-189, BDNF-inducing stacks, Lion’s Mane (high doses). Potential reactions may include anxiety, insomnia, neuroexcitation.
- Dopaminergic Agents: Possible amplification of stimulants (amphetamine, methylphenidate), bromantane, and MAO inhibitors. Potential reactions may include agitation, insomnia, and sympathetic activation.
- Growth-Factor/Regenerative Peptides: Theoretical additive proliferation signaling with IGF-1 LR3, GH secretagogues (CJC/Ipamorelin), and TB- 500, and BPC-157.
- Anti-Cancer Therapies: Potential antagonism with c-MET inhibitors and chemotherapy relying on growth suppression.
USE WITH CAUTION/UNDER CLOSE MEDICAL SUPERVISION
- Bipolar or severe anxiety disorders
- Epilepsy or seizure history
- Brain tumors
- Retinal vascular disease
- Autoimmune CNS disease
CONTRAINDICATIONS
- History of metastatic cancer
- Precancerous lesions under monitoring
- Pregnancy or breastfeeding (no safety data)
- Pediatric use
DIHEXA: CYCLING AND OTHER DOSING CONSIDERATIONS
8-12 week cycles followed by 4-6 week washout period
Recommend morning dosing (may cause sleep disturbances for some)
Take on empty stomach and wait for 30 minutes before eating
Oral administration
Take 1-4 capsules (5-20mg) per day, either at once or divided into 3 doses