Research Dosing

Melanotan-2

🔴 IMPORTANT: Read This Before Proceeding With Dosing
Go to the Prep & Injection Guide for proper reconstitution, syringe sizing, and injection protocols. Mistakes here can compromise your research.

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Melanotan-2

Melanotan-2 is an analog of the human peptide alpha-melanocyte-stimulating hormone (a-MSH), that induces skin tanning. It plays a role in stimulating the production of melanin, a pigment that gives color to the skin, hair, and eyes. By increasing the amount of melanin in the skin, Melanotan-2 offers a degree of protection from UV rays, as more melanin in the skin means the skin has a better ability to protect itself from sun damage.

It allows for an accelerated rate of pigment production under much lower levels of UV exposure than would otherwise be necessary. This reduces the time spent under UV light, which in turn helps to prevent skin cancer and sunburn.

Benefits

  • Reduces sun damage
  • Prevents melanoma
  • Increases sexual arousal and sexual desire
  • May produce erections for men with Erectile Dysfunction (ED)
  • Helps treat certain skin conditions such as rosacea
  • Helps attain uniform skin tone

Other Therapeutic Applications

Photosensitivity disorders: Melanotan-2 has been studied for conditions like erythropoietic protoporphyria (EPP), a rare genetic disorder that makes skin extremely sensitive to sunlight. The increased melanin reduces symptoms, allowing individuals to tolerate sunlight better.

Vitiligo research: Some research suggests potential use in helping to manage conditions like vitiligo by promoting repigmentation in affected areas.

Side Effects

  • Facial flushing — temporary warmth and redness of the skin
  • Nausea
  • Vomiting (less common)
  • New or darkening freckles
  • Decreased appetite which may lead to weight loss
  • Stomach cramps immediately following injections

Less common but more severe side effects may include:

  • Fatigue
  • Headaches
  • Dizziness
  • Darkening of the lips and gums — some users notice changes in pigmentation in areas other than the skin

Contraindications

Do not take if you are pregnant or nursing.

MELANOTAN-2: 10MG — RECONSTITUTION AND DOSING

6-week cycle followed by 3-6 week washout period

Daily Dosing

Subcutaneous Administration


Mix with 3mL (300 units) of BAC water

Weeks 1 & 2: 8 units (250mcg), 1x/day, daily
Weeks 3 & 4: 15 units (500mcg), 1x/day, daily

Weeks 5 & 6: 30 units (1mg), 1x/day, daily

Stacking Suggestions

  • Combine with GH-releasing peptides like CJC-1295/Ipamorelin for enhanced skin regeneration and body composition synergy
  • Stack with PT-141 to amplify libido and sexual performance benefits
  • Use with B12 injections to support energy and appetite regulation, especially if experiencing nausea or reduced hunger
  • Can be paired with Glutathione or Vitamin C for even skin tone and antioxidant protection