🔴 IMPORTANT: Read This Before Proceeding With Dosing
Go to the Prep & Injection Guide for proper reconstitution, syringe sizing, and injection protocols. Mistakes here can compromise your research.
👉 Click here to read the Prep & Injection Guide
SS-31, also known as Elamipretide, Bendavia, or MTP-131, is a synthetic peptide that targets and improves mitochondrial function. Mitochondria generate ATP (the body’s primary energy molecule), regulate cellular homeostasis, and impact nearly all physiological systems. SS-31 is a mitochondrial-targeted antioxidant with extensive therapeutic potential: mitigating oxidative stress, suppressing inflammation, maintaining mitochondrial health, and preventing cellular apoptosis.
It has several advantages over natural antioxidants and plays a key role in treating mitochondrial dysfunction-related disorders.
BENEFITS
- Increased energy (most potent energy-boosting peptide available)
- Neutralizes free radicals and reverses oxidative stress damage
- Anti-aging
- Anti-inflammatory (including neuroinflammation)
- Supports memory and cognition
- Antifibrotic
- Beneficial for kidney disease (activates AMPK pathway)
- Fights insulin resistance
- May prevent or mitigate symptoms of:
- Cardiovascular disease
- Neurodegenerative conditions
- Asthma and COPD
- Age-related macular degeneration
- Cancer
- Barth syndrome
- Primary mitochondrial myopathy
- Duchenne muscular dystrophy
- Friedrich’s ataxia
POSSIBLE SIDE EFFECTS
- Injection site irritation (redness, swelling, and/or itching)
- Gas
- Gastrointestinal upset
- Headache
- Dizziness
- Signs of an allergic reaction include: fast, erratic heartbeat; profuse sweating; shortness of breath; confusion; severe weakness; loss of coordination; stiff muscles and high fever; eye symptoms including blurred vision, tunnel vision, eye pain, swelling of the eyes, seeing halos around lights
CONTRAINDICATIONS
- Do not use if pregnant or breastfeeding
- Do not use if hypersensitive to mitochondrial-targeted compounds
SS-31: RECONSTITUTION & DOSING
8-12 week cycle followed by 4-8 week washout period
Daily Dosing
Dose in the A.M.- dosing at a consistent time of day is recommended
Take in a fasted state
Subcutaneous administration
*Unlike most protocols, I assigned dosing protocols appropriate to each vial size, since to attempt to use 10mg vials for even a low-end standard SS-31 protocol would be extremely expensive. So while technically you COULD use 10mg vials for any of the protocols, it makes zero sense to do so.
SS-31: 10MG DOSING PROTOCOLS (Only recommended when running as supportive precedent to MOTS-C cycle)
Mix with 1mL (100 units) of BAC water
Take 10 units, 1x/day, for 10-14 days prior to start of MOTS-C cycle
SS-31: 30MG DOSING PROTOCOLS
LOW DOSE PROTOCOL
Mix with 2mL (200 units) of BAC water
- Week 1: 7 units (1mg), 1x/day, 5 days/week
- Weeks 2–5: 14 units (2mg), 1x/day, 5 days/week
- Weeks 6–8: 21 units (3mg), 1x/day, 3 days/week
- Weeks 9–12: 28 units (4mg), 1x/day, 3 days/week
STANDARD PROTOCOL
Mix with 2mL (200 units) of BAC water
Take 33 units (5mg), 3-7 days per week, for 8-12 weeks
MAXIMUM PROTOCOL
Mix with 2mL (200 units) of BAC water
- Week 1: 10 units (1.5mg), 1x/day, 5 days/week
- Weeks 2–5: 20 units (3mg), 1x/day, 5 days/week
- Weeks 6–8: 30 units (4.5mg), 1x/day, 3 days/week
- Weeks 9–12: 40 units (6mg), 1x/day, 3 days/week
Stacking Suggestions
- MOTS-C – run SS-31 before a MOTS-C cycle for maximum mitochondrial optimization. SS-31 primes the mitochondria, MOTS-C boosts cellular adaptation and metabolic health (Follow standard protocol for 10-14 days prior to start of MOTS-C protocol)
- NAD+ – supports ATP production and cellular repair when paired with SS-31
- Glutathione – enhances antioxidant defense and detoxification during oxidative stress repair
- CJC-1295 / Ipamorelin – supports cellular regeneration and recovery alongside mitochondrial repair
- AOD-9604 – assists with fat metabolism during energy-focused SS-31 cycles
- BPC-157 – promotes systemic healing and combats inflammatory stress