🔴 IMPORTANT: Read This Before Proceeding With Dosing
Go to the Prep & Injection Guide for proper reconstitution, syringe sizing, and injection protocols. Mistakes here can compromise your research.
👉 Click here to read the Prep & Injection Guide
Tirzepatide
Tirzepatide was originally developed to treat Type-2 diabetes but has since become a leading anti-obesity medication. It is a dual agonist of the GLP-1 and GIP receptors — meaning it activates two distinct hormonal pathways to reduce appetite, improve metabolic rate, and support sustained weight loss.
Unlike its predecessor Semaglutide (which only targets GLP-1), Tirzepatide showed 5–7% more weight loss in clinical trials. Compared to Retatrutide, a triple agonist, Tirzepatide accomplished nearly the same weight loss but over a longer period (72 weeks vs. 48).
Mechanism of Action
- GLP-1: Suppresses appetite and increases feelings of fullness after eating.
- GIP: Promotes insulin secretion and supports energy balance through receptors in the hypothalamus.
Benefits
- Average weight loss of 24.7% after 72 weeks
- Reduces appetite and cravings
- Enhances satiety and energy balance
- Supports fat oxidation and metabolism
- Improves insulin sensitivity and blood sugar control
Possible Side Effects (often mild and temporary; affected only ~25% in trials)
- Injection site reaction (redness, swelling, itching)
- Nausea
- Vomiting
- Diarrhea
- Constipation
- Decreased appetite
- Fatigue
- Dyspepsia (indigestion)
- Abdominal pain
- Burping (may have sulfur smell)
- Hair loss
Rare but serious risks
- Thyroid C-Cell Tumors
- Pancreatitis
- Gastroparesis (stomach paralysis)
- Hypoglycemia (if used with insulin)
- Gallbladder disease
- Kidney issues (linked to dehydration)
- Pulmonary aspiration under anesthesia – ALWAYS disclose Tirzepatide use to surgical teams
Contraindications
- Do not use if pregnant or breastfeeding
- Do not use with a personal or family history of Medullary Thyroid Carcinoma or MEN 2 (Multiple Endocrine Neoplasia)
- Do not use if you have Type-1 diabetes, diabetic retinopathy, or severe GI disease
- Do not use if you are allergic or hypersensitive to Tirzepatide
TIRZEPATIDE: 10MG
Mix with 0.5mL (50 units) of BAC water
Dose 1 day of each week (once every 7 days), always on the same day of the week
Stay on each dose for a minimum of 4 weeks before raising to the next dose
Subcutaneous Dosing
*Please note that those who are transferring to Tirzepatide from another GLP peptide, your starting dose is 5mg, NOT 2.5mg
2.5mg = 12 units
5 mg = 25 units
7.5mg = 38 units
10mg = 50 units
TIRZEPATIDE: 30MG
Mix with 1.5mL (150 units) of BAC water
Dose 1 day of each week (once every 7 days), always on the same day of the week
Stay on each dose for a minimum of 4 weeks before increasing
Subcutaneous Dosing
*Please note that those who are transferring to Tirzepatide from another GLP peptide, your starting dose is 5mg, NOT 2.5mg
2.5mg = 12 units
5 mg = 25 units
7.5mg = 38 units
10mg = 50 units
12.5mg = 62 units
15mg = 75 units
TIRZEPATIDE: 60MG Mix with 3mL (300 units) of BAC water
Dose 1 day of each week (once every 7 days), always on the same day of the week
Stay on each dose for a minimum of 4 weeks before increasing
Subcutaneous Dosing
*Please note that those who are transferring to Tirzepatide from another GLP peptide, your starting dose is 5mg, NOT 2.5mg
2.5mg = 12 units
5 mg = 25 units
7.5mg = 38 units
10mg = 50 units
12.5mg = 62 units
15mg = 75 units
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Stacking Suggestions
- AOD-9604 – enhances fat breakdown and further accelerates weight loss alongside appetite suppression
- Tesamorelin – synergistic for fat reduction, especially visceral fat and metabolic regulation
- Semax or Selank – manage mood and cognitive function while adjusting to appetite changes
- NAD+ or MOTS-C – support energy, mitochondrial efficiency, and metabolism while on a caloric deficit
- BPC-157 – beneficial for gut repair if experiencing nausea, indigestion, or stomach discomfort
- CJC-1295 / Ipamorelin – for muscle maintenance and enhanced metabolic recovery while losing fat