Research Dosing

B12 (Methylcobalamin)

🔴 IMPORTANT: Read This Before Proceeding With Dosing
Go to the Prep & Injection Guide for proper reconstitution, syringe sizing, and injection protocols. Mistakes here can compromise your research.

👉 Click here to read the Prep & Injection Guide

BENEFITS

  • More energy!
  • Boosts metabolism; assists in the breakdown of carbohydrates, proteins
  • Less brain fog (B12 is essential for the myelin coating on your nerves, which improves brain function and enhances mental clarity)
  • Boosts cellular energy
  • Helps the liver process chemical waste
  • Supports hormone production
  • Regulates blood sugar
  • Breaks down carbohydrates
  • Helps mood and focus
  • Combats stress
  • Helps methylation and detox pathways
  • Helps with numbness and tingling in neuropathy patients

SIGNS OF B12 DEFICIENCY

  • Fatigue
  • Shortness of breath
  • Orthostatic Hypotension
  • Insomnia
  • Loss of concentration and memory
  • Depression
  • Muscle weakness
  • Irritability
  • Elevated heart rate
  • Decreased immune function
  • Burning in the mouth and tongue
  • Unexpected, sudden blurred vision
  • Balance problems

SYMPTOMS OF EXCESS BUILDUP OF B IN SYSTEM

  • Headaches
  • Nausea
  • Vomiting
  • Diarrhea
  • Skin rashes (itching, rashes, acne)

MORE SERIOUS SYMPTOMS OF EXCESS B IN SYSTEM

  • Heart problems
  • Blood clots
  • Neurological symptoms including tingling, numbness, confusion, and disorientation

CONTRAINDICATIONS

  • Do not use supplemental B12 if you have chronic kidney problems

B12 DOSING AND ADMINISTRATION

Take in the morning

May be taken with or without food

INTRAMUSCULAR ADMINISTRATION PREFERRED; Subcutaneous acceptable but less effective

STANDARD PROTOCOL

Weeks 1-4: 50 units (5,000mcg) 1x per week

Maintenance (after the first 4 weeks): 25-50 units (2,500-5,000mcg) 1x per month

MAXIMUM PROTOCOL

Weeks 1-10: 50 units (5,000mcg) 1x per week

Maintenance (after the first 10 weeks): 50 units (5,000mcg) 1x per month

STACKING SUGGESTIONS

  • MIC+C (Lipo-C) – Complements B12 for fat metabolism, liver detox, and increased energy
  • NAD+ – Synergistic cellular energy support and mitochondrial optimization
  • Tirzepatide or Semaglutide – Helps counter potential B12 depletion caused by GLP-1 receptor agonists
  • Glutathione – Supports antioxidant regeneration and detox pathways alongside B12
  • Folate (Methylfolate) – Pairs with B12 for improved methylation and homocysteine regulation