Research Dosing

5-Amino-1MQ

🔴 IMPORTANT: Read This Before Proceeding With Dosing
Go to the Prep & Injection Guide for proper reconstitution, syringe sizing, and injection protocols. Mistakes here can compromise your research.

👉 Click here to read the Prep & Injection Guide

5-Amino-1MQ

5-Amino-1MQ is a small molecule compound designed to inhibit the enzyme NNMT (nicotinamide N-methyltransferase), which plays a key role in metabolic regulation and fat cell activity. By suppressing NNMT, 5-Amino-1MQ increases NAD⁺ levels and helps to accelerate energy metabolism, support healthy body composition, and reduce fat mass—especially visceral fat. It has gained attention for its potential to improve insulin sensitivity, mitochondrial function, and cellular repair, making it a popular option in fat loss, longevity, and athletic performance protocols.

Key Benefits

  • Promotes rapid fat loss without muscle breakdown
  • Inhibits fat cell growth and reduces existing fat deposits
  • Boosts NAD⁺ levels and mitochondrial energy production
  • Improves insulin sensitivity and glucose tolerance
  • Enhances physical endurance and energy
  • Supports cellular longevity and anti-aging effects
  • May assist in reducing inflammation and oxidative stress

Mechanism of Action

5-Amino-1MQ works primarily by:

  • NNMT Inhibition: Suppresses the enzyme responsible for downregulating energy metabolism in fat cells
  • NAD⁺ Elevation: Increases intracellular NAD⁺, enhancing mitochondrial function and energy production
  • Mitochondrial Optimization: Promotes thermogenesis and lipid oxidation via improved mitochondrial efficiency

The result is an upregulation of cellular metabolism, reduced fat accumulation, and improved lean body mass.

Possible Side Effects

Common (usually temporary and mild):

  • Headache
  • Mild fatigue
  • Digestive discomfort (bloating, nausea)
  • Mild increase in heart rate

Rare:

  • Skin irritation or redness at injection site
  • Dizziness or jitteriness
  • Temporary sleep disturbances

Side Effect Management

  • Stay hydrated and eat balanced meals during the protocol
  • Reduce dosage if fatigue or nausea occurs
  • Use smaller split doses if needed to increase tolerance

Contraindications

Do NOT use 5-Amino-1MQ if:

  • You are pregnant or breastfeeding
  • You have uncontrolled cardiovascular conditions
  • You have liver or kidney impairment
  • You are allergic to any excipients or BAC
  • You are on medications that alter NAD metabolism without physician oversight

Dosing Protocol

5-Amino-1MQ: 10 mg vial
Mix with 3 mL (300 units) of bacteriostatic water
Administer subcutaneously or intramuscularly using insulin syringes
Cycle length: 8–12 weeks
Follow with a 2–4 week washout period

Standard Protocol

  • Week 1: 5 units (150 mcg), once daily
  • Weeks 2–4: 9 units (300 mcg), once daily
  • Weeks 5–8: 14 units (450 mcg), once daily
  • Weeks 9–12 (optional): 18 units (600 mcg), once daily

Maximum Protocol

  • Week 1: 9 units (300 mcg), once daily
  • Week 2: 14 units (450 mcg), once daily
  • Weeks 3–4: 18 units (600 mcg), once daily
  • Weeks 5–8: 23 units (750 mcg), once daily
  • Weeks 9–12: 30 units (1,000 mcg), once daily

Stacking Suggestions

  • AOD-9604 – Targets fat loss with no muscle catabolism
  • CJC-1295 + Ipamorelin – Boosts growth hormone for enhanced metabolic effect
  • GLP-1 Agonists (Semaglutide, Tirzepatide) – Supports appetite suppression and insulin regulation
  • Glutathione or NAD+ Precursors – To amplify anti-aging and mitochondrial repair benefits