Tesofensine is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) that was originally researched Parkinson’s and Alzheimer’s adjunct but was quickly adopted as an anti-obesity drug. It is a potent appetite suppressant known to boost energy, regulate blood sugar, improve sleep quality, improve cognitive heath, stabilize moods, manage symptoms of ADHD, and even combat alcohol dependency.

Weight Loss

• Appetite suppression
• Increases energy
• Improves blood sugar levels by improving insulin sensitivity and glucose metabolism
• Increases resting energy expenditure
• Increases fat oxidation
• Reduces fat tissue
• Boosts metabolism
• Promotes feelings of satiety
• Targets abdominal fat
• Reduces cravings

Additional Benefits

• Helps preserve cognitive health by indirectly increasing cholinergic neurotransmission, a process in which nerve cells relay messages to each other; this has beneficial on various areas in the CNS and cognitive health, including learning, memory, and thinking skills
• May help treat brain disorders such as Alzheimer’s and Parkinson’s
• Increases brain-derived neurotrophic factor (BDNF), triggering an antidepressant effect
• Functions as an anti-anxiety agent in those with both depression and anxiety
• Increases serotonin, noradrenaline, and dopamine
• Reduces blood sugar
• Likely linked to the increased levels of dopamine, Tesofensine contributes to the desire for sexual activity, better erections, and better ejaculation.
• Strongly advised for those with a binge eating disorder
• Improves symptoms of ADHD, which are strongly linked with low levels of dopamine and serotonin
• Treats serotonin-deficient insomnia
• The boost in dopamine can help in the cure of alcohol addiction due to the boost in neurotransmitter levels

Possible Side Effects

• Dry mouth
• Slight increase in blood pressure and pulse (dose dependent)
• Constipation
• Diarrhea
• Nausea
• Headache
• Insomnia
• Effects on mood
• Exacerbation of psychiatric conditions

Contraindications & Warnings

• Do not use if you are pregnant or nursing
• Do not use if you have preexisting cardiovascular disease, uncontrolled hypertension, arrhythmias, or are at risk of ischemic disease
• Do not use if you have uncontrolled bipolar disorder, uncontrolled depression, schizophrenia, or other serious psychiatric history
• Do not use if you have recently taken or are currently taking monoamine oxidase inhibitors (MAOIs)
• Do not use if you have glaucoma (as tesofensine may worsen intraocular pressure)
• Do not use if you are currently using any serotonin agent, include SSRIs, SNRIs, tricyclic antidepressants, MAOIs, and so on. Examples include Prozac, Zoloft/Sertraline, Wellbutrin/Zyban/Buproprion, Celexa, Paxil, Lexapro, Effexor, Cymbalta, Trzodone, Subutex/Buprenorphine, Zyprexa/Olanzapine, Dolophone/Methadose/Methadone, Meperidine, Nucynta/Tapentadol, Carbatrol/Tegretol/Carbamazepine, Thorazine/Chrlorpromazine, Peroactin/Cyproheptadine, Depakote/Depakene/Valproic Acid, Methamphetamine, Cocaine, 3,4-Methylenedioxymethamphetamine, Remeron/Mirtazapine, Almotriptan, Relpax/Eletriptan, Frova/Frovatroptan, Amerge/Naratriptan, Rizatriptan, Imitrex/Sumatriptan, Zolmitriptan, Buspar/Buspirone, Zofran/Ondansetron, Kytril/Granisetron, Prinivil/Zestril/Lisinopril, Demerol/Meperidine, Reglan/Metoclopramide, Pristiq, Fetzima, Amitryptiline, Imipramine, Doxepin, Nortriptyline, Marplan, Nardil, Parnate, Emsam, Tramadol, St. John’s Wort

Use of Tesofensine with Serotonin agents may cause Serotonin Syndrome. Symptoms of Serotonin Syndrome include: Agitation, Confusion, Anxiety, Restlessness, Excitement, Delirium, Coma, Hypertension, Tachycardia, Diaphoresis, Hyperthermia, Nausea, Vomiting, Diarrhea, Mydriasis, Tremor, Clonus, Hyperreflexia, Muscle Rigidity, Akathisia, Rhabdomyolosis, Myoglobinuria, Metabolic Acidosis, Renal Failure, Respiratory Failure, Seizures, Death

TESOFENSINE: 500MCG — DOSING

Tesofensine has a very long half-life; one pill per day is sufficient.