Research Dosing

Cagrilinitide

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Go to the Prep & Injection Guide for proper reconstitution, syringe sizing, and injection protocols. Mistakes here can compromise your research.

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Cagrilinitide (or “Cagri”) is a long-acting, lipidated, albumin-binding amylin agonist that targets both amylin and calcitonin receptors. It is used in the treatment of obesity, either on its own or in combination with GLP-1 receptor agonists. Amylin is co-secreted with insulin from pancreatic beta cells and regulates appetite, satiety, gastric emptying, and glucose control.

Combining Cagrilinitide with a GLP-1 like Semaglutide has a synergistic effect, amplifying weight loss beyond what either peptide achieves independently. Other benefits include improved circulation, reduced blood pressure, enhanced bone-building activity, and vasodilation.

Outcomes

  • 6–10% body weight loss at 26 weeks (Cagrilinitide alone)
  • 23–24.4% body weight loss at 68 weeks (combined with Semaglutide)
  • Synergistic effect: up to 8% more weight loss vs. Semaglutide alone

Possible Side Effects

  • Injection site reaction (redness, swelling, itching, hives)
  • Nausea
  • Vomiting
  • Constipation
  • Fatigue
  • Headache
  • Diarrhea
  • Heartburn
  • Gallbladder stones (rare)

Dosing

CAGRILINITIDE: 10MG
Mix with 2mL (200 units) of BAC water
Subcutaneous Administration
16-week cycle followed by a 4–6 week washout period

  • Week 1: 8 units (400mcg)
  • Weeks 2 & 3: 15 units (750mcg)
  • Weeks 4 & 5: 24 units (1.2mg)
  • Weeks 6 & 7: 34 units (1.7mg)
  • Weeks 8 & 9: 44 units (2.2mg)
  • Weeks 10-16: 54 units (2.7mg)

Important Notes

  • Always dose on the same day each week
  • Ensure adequate hydration throughout the cycle
  • Do not exceed 16 consecutive weeks of use
  • Anti-Cagri antibodies may form with extended use (46–73% of users)

Stacking Suggestions

  • Semaglutide or Tirzepatide – Boosts appetite suppression and fat loss via GLP-1 synergy
  • Tesofensine – Enhances energy expenditure and thermogenesis
  • L-Carnitine – Supports fat metabolism and energy conversion
  • AOD-9604 – Encourages lipolysis and body fat reduction without affecting blood sugar