Research Dosing

IGF1- LR3

🔴 IMPORTANT: Read This Before Proceeding With Dosing
Go to the Prep & Injection Guide for proper reconstitution, syringe sizing, and injection protocols. Mistakes here can compromise your research.

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IGF-1 LR3 (Insulin-like Growth Factor-1 Long R3)

IGF1-LR3 (Insulin-like Growth Factor-1 Long R3) is a modified version of the hormone known as Insulin-like Growth Factor (IGF or IGF-1). IGF-1 is a hormone naturally found in your blood, which manages the effects of growth hormone (GH) in your body. The “insulin” portion of the name refers to the fact that IGF-1 has insulin-like actions in some tissues. It does decrease blood sugar levels, but not nearly to the extent that insulin does. Its fundamental mechanism is to stimulate growth, such as in epidermal, platelet-derived, and nerve growth factors. IGF’s differ from other growth factors in that they are the only ones with well-described endocrine actions in human. The endocrine system produces and releases hormones and regulates many body functions, including metabolism, growth, mood, and reproduction.

The primary difference between IGF-1 and IGF-1 LR3 is the difference in their respective half-lives. IGF-1 is only active in the system for a very short period of time, whereas IGF-1 LR3 has a much longer half life of 20–30 hours. The longer half-life is advantageous because it is more potent and its effects can be exerted throughout the entire day. IGF-1 LR3 results in better muscle growth because of its lower binding affinity for proteins like IGFBP-3.

Benefits

  • Enhances muscle strength and mass – one of the fastest muscle-building agents available
  • Stimulates the proliferation of muscle satellite cells that help repair damaged muscle tissue (from exercise and/or injury)
  • Activates signaling pathways that promote muscle protein synthesis and stop muscle protein breakdown
  • Promotes and manages the effects of GH in the body
  • Reduces inflammation in the body
  • Regulates blood sugar
  • Promotes cell growth
  • Upregulates metabolism
  • Promotes lipolysis (the reduction of body fat; also prevents new stores of fat cells from accumulating)
  • Inhibits glucose transport into cells, allowing the body to use the glucose for energy
  • Reduces hunger and food cravings
  • Boosts overall energy levels

TRT and IGF1-LR3 are a complementary stack resulting in:

  • Increased strength
  • Better endurance
  • Accelerated muscle gains
  • Minimal recovery times

Possible Side Effects

  • Injection site reaction (Swelling, redness, and/or itching)
  • Muscle and joint pain
  • Fatigue
  • Headache
  • Nausea
  • Low blood sugar
  • Abdominal discomfort and bloating
  • Changes in sexual function

At high doses or with long-term use, may result in:

  • Irregular heartbeat
  • Overabundant tissue growth (especially in the face)
  • Acromegalic cardiomyopathy (enlargement and weakening of the heart)

Keep dosage as low as possible for as long as possible. Titrate up only as necessary.

Reconstitution and Dosing

IGF-1 LR3: 1MG
8-week cycle followed by a 4-8 week washout period

Daily Dosing (7 days/week)

Subcutaneous Administration

Mix 1GF1-LR3: 1MG with 3mL (300 units) of BAC water

Dosing Schedule

  • Week 1: 10 units (33mcg), 1x/day
  • Week 2: 15 units (50mcg), 1x/day
  • Weeks 3–4: 23 units (75mcg), 1x/day
  • Weeks 5–8: 30 units (100mcg), 1x/day

Timing

  • Dose in the morning on an empty stomach for maximum receptor sensitivity
  • Dose within 30 minutes after workout to enhance recovery and muscle growth

Stacking & Pairing Suggestions

  • CJC-1295 / Ipamorelin Combo – for enhanced GH release and synergy with IGF-1 LR3
  • Tesamorelin – to reduce visceral fat while maximizing lean growth
  • MK-677 – oral GH booster that complements IGF-driven pathways
  • BPC-157 or TB-500 – joint and soft tissue repair while building muscle
  • AOD-9604 – for cutting cycles and fat loss support
  • Tirzepatide – improves insulin sensitivity while offsetting IGF-induced blood sugar shifts