Research Dosing

Survodutide

🔴 IMPORTANT: Read This Before Proceeding With Dosing
Go to the Prep & Injection Guide for proper reconstitution, syringe sizing, and injection protocols. Mistakes here can compromise your research.

👉 Click here to read the Prep & Injection Guide

Survodutide

Survodutide is a dual agonist of the GLP-1 and glucagon receptors, originally developed as a treatment for Type-2 Diabetes and obesity. Like other GLP-1 drugs, it suppresses appetite, increases fat oxidation, and supports metabolic activity. Survodutide has also shown promise as a treatment for non-cirrhotic metabolic-dysfunction-associated steatohepatitis (MASH) and moderate liver fibrosis (F2–F3 stage).

Benefits

  • At 46 weeks, participants lost an average of 6 inches from waist circumference
  • 19% total body weight loss at 4.8mg weekly
  • Significant reduction in blood pressure at 2.4mg or higher
  • Potentially beneficial for cardiovascular health
  • Ongoing weight loss past 46 weeks suggests longer-term use may yield greater fat reduction

Possible Side Effects

Survodutide shows milder side effects than other GLP-1 drugs in clinical trials. Reported side effects include:

  • Injection site irritation (redness, swelling, itching)
  • Nausea
  • Vomiting
  • Diarrhea

Contraindications

  • Monitor patients on antihypertensive medications — Survodutide may interact with blood pressure meds
  • Do not take if pregnant or breastfeeding
  • Do not stop all blood pressure meds without consulting a physician — this may offset Survodutide’s benefits

Reconstitution and Dosing

Survodutide: 10mg
Mix with 1.5mL (150 units) of BAC water
Subcutaneous injection, once weekly

  • Always inject on the same day each week
  • Stay on each dose for at least 4 weeks before increasing
  • Doses are raised in 0.8mg increments

Dosing Chart

  • 24 units = 1.6mg (starting dose)
  • 36 units = 2.4mg
  • 48 units = 3.2mg
  • 60 units = 4mg
  • 72 units = 4.8mg (clinical trial dose for 19% weight loss)
  • 84 units = 5.6mg
  • 96 units = 6.4mg (maximum dose)

Begin with 24 units = 1.6mg, stay at that dose for at least 4 weeks before considering a dosage increase.

Stacking Suggestions

  • Tirzepatide or Semaglutide (alternate between cycles to prevent GLP-1 receptor desensitization)
  • NAD+ or MOTS-C – enhances cellular energy production and mitochondrial repair alongside fat loss
  • AOD-9604 – further supports lipolysis during Survodutide’s appetite-suppressing phase
  • L-Carnitine Injections – promotes fat transport into mitochondria for oxidation
  • Glutathione – reduces oxidative stress and supports liver function (especially in MASH patients)
  • CJC-1295/Ipamorelin – enhances lean muscle gain during weight loss phases

For metabolic and liver optimization, Survodutide + Glutathione + NAD+ is a powerful triad. For fat loss, stack with AOD-9604 and CJC-1295/Ipamorelin to preserve lean mass and recover faster.