TESOFENSINE, 500MCG CAPSULES

ORAL FORMULATION INFORMATION AND PROTOCOLS

Tesofensine is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) that was originally researched Parkinson’s and Alzheimer’s adjunct but was quickly adopted as an anti-obesity drug. It is a potent appetite suppressant known to boost energy, regulate blood sugar, improve sleep quality, improve cognitive heath, stabilize moods, manage symptoms of ADHD, and even combat alcohol dependency.

METABOLIC BENEFITS

  • Appetite suppression
  • Increases energy
  • Improves blood sugar levels by improving insulin sensitivity and glucose metabolism
  • Increases resting energy expenditure
  • Increases fat oxidation
  • Reduces fat tissue
  • Boosts metabolism
  • Promotes feelings of satiety
  • Targets abdominal fat
  • Reduces cravings

ADDITIONAL USES, APPLICATIONS, & BENEFITS

  • Helps preserve cognitive health by indirectly increasing cholinergic neurotransmission, a process in which nerve cells relay messages to each other; this has beneficial on various areas in the CNS and cognitive health, including learning, memory, and thinking skills
  • May help treat brain disorders such as Alzheimer’s and Parkinson’s
  • Increases brain-derived neurotrophic factor (BDNF), triggering an antidepressant effect
  • Functions as an anti-anxiety agent in those with both depression and anxiety
  • Increases serotonin, noradrenaline, and dopamine
  • Reduces blood sugar
  • Likely linked to the increased levels of dopamine, Tesofensine contributes to the desire for sexual activity, better erections, and better ejaculation.
  • Strongly advised for those with a binge eating disorder
  • Improves symptoms of ADHD, which are strongly linked with low levels of dopamine and serotonin
  • Treats serotonin-deficient insomnia
  • The boost in dopamine can help in the cure of alcohol addiction due to the boost in neurotransmitter levels

POSSIBLE SIDE EFFECTS

  • Dry mouth
  • Slight increase in blood pressure and pulse (dose dependent)
  • Constipation
  • Diarrhea
  • Nausea
  • Headache
  • Insomnia
  • Effects on mood
  • Exacerbation of psychiatric conditions

INTERACTIONS AND CONTRAINDICATIONS

  • Do not use if you are pregnant or nursing
  • Do not use if you have preexisting cardiovascular disease, uncontrolled hypertension, arrhythmias, or are at risk of ischemic disease
  • Do not use if you have uncontrolled bipolar disorder, uncontrolled depression, schizophrenia, or other serious psychiatric history
  • Do not use if you have recently taken or are currently taking monoamine oxidase inhibitors (MAOIs)
  • Do not use if you have glaucoma (as tesofensine may worsen intraocular pressure)
  • Do not use if you are currently using any serotonin agent, include SSRIs, SNRIs, tricyclic antidepressants, MAOIs, and so on. Examples include Prozac, Zoloft/Sertraline, Wellbutrin/Zyban/Buproprion, Celexa, Paxil, Lexapro, Effexor, Cymbalta, Trzodone, Subutex/Buprenorphine, Zyprexa/Olanzapine, Dolophone/Methadose/Methadone, Meperidine, Nucynta/Tapentadol, Carbatrol/Tegretol/Carbamazepine, Thorazine/Chrlorpromazine, Peroactin/Cyproheptadine, Depakote/Depakene/Valproic Acid, Methamphetamine, Cocaine, 3,4-Methylenedioxymethamphetamine, Remeron/Mirtazapine, Almotriptan, Relpax/Eletriptan, Frova/Frovatroptan, Amerge/Naratriptan, Rizatriptan, Imitrex/Sumatriptan, Zolmitriptan, Buspar/Buspirone, Zofran/Ondansetron, Kytril/Granisetron, Prinivil/Zestril/Lisinopril, Demerol/Meperidine, Reglan/Metoclopramide, Pristiq, Fetzima, Amitryptiline, Imipramine, Doxepin, Nortriptyline, Marplan, Nardil, Parnate, Emsam, Tramadol, St. John’s Wort

USE OF TESOFENSINE WITH SEROTONIN AGENTS MAY CAUSE SEROTONIN SYNDROME (AKA SEROTONIN TOXICITY), A POTENTIALLY LIFE-THREATENING DRUG REACTION CAUSED BY EXCESS LEVELS OF SEROTONIN FLOODING THE CENTRAL NERVOUS SYSTEM.

SYMPTOMS OF SEROTONIN TOXICITY INCLUDE:

  • Agitation
  • Confusion
  • Anxiety
  • Restlessness
  • Excitement
  • Delirium
  • Coma
  • Hypertension
  • Tachycardia
  • Diaphoresis
  • Hyperthermia
  • Nausea
  • Vomiting
  • Diarrhea
  • Mydriasis
  • Tremor
  • Clonus
  • Hyperreflexia
  • Muscle Rigidity
  • Akathisia
  • Rhabdomyalosis
  • Myoglobinuria
  • Metabolic acidosis
  • Renal Failure
  • Respiratory Failure
  • Seizures
  • Death

IF YOU SUSPECT SOMEONE OF HAVING SEROTONIN TOXICITY, ANY AND ALL SEROTONERGIC AGENTS SHOULD BE STOPPED IMMEDIATELY, AND THEY SHOULD BE TRANSPORTED TO THE EMERGENCY ROOM FOR INTENSIVE MONITORING, IV THERAPY, COOLING MEASURES, OR THE ADMINISTRATION OF AGITATION-PREVENTING, SEROTONIN-BLOCKING MEDICATIONS.

TESOFENSINE: 500MCG

DOSING

CYCLE LENGTH: 8-12 week cycles followed by 4-6 week washout period

FREQUENCY: Daily dosing

TIMING: Dose in the morning to early afternoon

FASTING REQUIREMENTS: You do not have to be fasted to dose; outcomes have proven to be essentially the same whether research participants had been fasting or had dosed with food in their stomachs

Take ONE (1) capsule per day, daily, for duration of cycle